Recent Publications

2022-2023

Walek KW, Stefan S, Lee JH, Puttigampala P, Kim AH, Park SW, Marchand PJ, Lesage F, Liu T, Huang YA, Boas DA, Moore C, Lee J. Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice. Nat Commun. 2023 May 24;14(1):2982. doi: 10.1038/s41467-023-38609-z. PubMed PMID: 37221202; PubMed Central PMCID: PMC10205707.

Lehoux M, Connolly K, Assetta B, Huang YA. The Generation and Functional Characterization of Human Microglia-Like Cells Derived from iPS and Embryonic Stem Cells. Methods Mol Biol. 2023;2683:69-78. doi: 10.1007/978-1-0716-3287-1_6. PubMed PMID: 37300767.

Connolly K, Lehoux M, Assetta B, Huang YA. Modeling Cellular Crosstalk of Neuroinflammation Axis by Tri-cultures of iPSC-Derived Human Microglia, Astrocytes, and Neurons. Methods Mol Biol. 2023;2683:79-87. doi: 10.1007/978-1-0716-3287-1_7. PubMed PMID: 37300768.

O'Rourke R, Erdemir GA, Huang YA. Assays of Monitoring and Measuring Autophagic Flux for iPSC-Derived Human Neurons and Other Brain Cell Types. Methods Mol Biol. 2023;2683:221-233. doi: 10.1007/978-1-0716-3287-1_18. PubMed PMID: 37300779.

Connolly K, Lehoux M, O'Rourke R, Assetta B, Erdemir GA, Elias JA, Lee CG, Huang YA. Potential role of chitinase-3-like protein 1 (CHI3L1/YKL-40) in neurodegeneration and Alzheimer's disease. Alzheimers Dement. 2023 Jan;19(1):9-24. doi: 10.1002/alz.12612. Epub 2022 Mar 2. PubMed PMID: 35234337; PubMed Central PMCID: PMC9437141.

~2021 (Selected)

Pak C, Danko T, Mirabella VR, Wang J, Liu Y, Vangipuram M, Grieder S, Zhang X, Ward T, Huang YA, Jin K, Dexheimer P, Bardes E, Mitelpunkt A, Ma J, McLachlan M, Moore JC, Qu P, Purmann C, Dage JL, Swanson BJ, Urban AE, Aronow BJ, Pang ZP, Levinson DF, Wernig M, Südhof TC. Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22). doi: 10.1073/pnas.2025598118. PubMed PMID: 34035170; PubMed Central PMCID: PMC8179243.

Assetta B, Tang C, Bian J, O'Rourke R, Connolly K, Brickler T, Chetty S, Huang YA. Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions. J Vis Exp. 2020 Nov 9;(165). doi: 10.3791/61778. PubMed PMID: 33226027; PubMed Central PMCID: PMC7739515.

Huang YA, Zhou B, Nabet AM, Wernig M, Südhof TC. Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk. J Neurosci. 2019 Sep 11;39(37):7408-7427. doi: 10.1523/JNEUROSCI.2994-18.2019. Epub 2019 Jul 22. PubMed PMID: 31331998; PubMed Central PMCID: PMC6759032.

Huang YA, Zhou B, Wernig M, Südhof TC. ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion. Cell. 2017 Jan 26;168(3):427-441.e21. doi: 10.1016/j.cell.2016.12.044. Epub 2017 Jan 19. PubMed PMID: 28111074; PubMed Central PMCID: PMC5310835.

Huang YW, Ruiz CR, Eyler EC, Lin K, Meffert MK. Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis. Cell. 2012 Mar 2;148(5):933-46. doi: 10.1016/j.cell.2012.01.036. PubMed PMID: 22385959; PubMed Central PMCID: PMC4074528.

Tang SC, Huang YW, Shieh JS, Huang SJ, Yip PK, Jeng JS. Dynamic cerebral autoregulation in carotid stenosis before and after carotid stenting. J Vasc Surg. 2008 Jul;48(1):88-92. doi: 10.1016/j.jvs.2008.02.025. Epub 2008 May 16. PubMed PMID: 18486427.

Tsai CF, Wu RM, Huang YW, Chen LL, Yip PK, Jeng JS. Transcranial color-coded sonography helps differentiation between idiopathic Parkinson's disease and vascular parkinsonism. J Neurol. 2007 Apr;254(4):501-7. doi: 10.1007/s00415-006-0403-9. Epub 2007 Mar 31. PubMed PMID: 17401518.

Huang YW, Jeng JS, Tsai CF, Chen LL, Wu RM. Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease. Mov Disord. 2007 Mar 15;22(4):550-5. doi: 10.1002/mds.21372. PubMed PMID: 17260344.